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Benign fibrous histiocytoma

Updated: 2017-08-18T01:01Z
Classification and external resources
ICD-10D23 (ILDS D23.L62)
Patient UKBenign fibrous histiocytoma
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Benign fibrous histiocytomas (also known as dermal dendrocytoma,[1] dermatofibroma,[2] fibrous dermatofibroma,[2] fibrous histiocytoma,[2] fibroma simplex,[1] nodular subepidermal fibrosis,[1] and sclerosing hemangioma[1]) are benign skin growths.[3]


Dermatofibromas are hard solitary slow-growing papules (rounded bumps) that may appear in a variety of colours, usually brownish to tan; they are often elevated or pedunculated. A dermatofibroma is associated with the dimple sign; by applying lateral pressure, there is a central depression of the dermatofibroma. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Dermatofibromas can be found anywhere on the body, but most often they are found on the legs and arms.[4] They occur most often in women; the male to female ratio is about 1:4.[5] The age group in which they most commonly occur is 20 to 45 years.

Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.[5] They are composed of disordered collagen laid down by fibroblasts. Dermatofibromas are classed as benign skin lesions, meaning they are completely harmless, though they may be confused with a variety of subcutaneous tumours.[6] Deep penetrating dermatofibromas may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.[7]

Dermatofibromas typically have a positive buttonhole sign, or central dimpling in the center.[8]

Immunohistochemical staining

Neoplasm CD34[1] Stromelysin-3[9] Factor XIIIa[5]
Dermatofibroma - + +
Dermatofibrosarcoma protuberans + - -

See also


  1. ^ a b c d e Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. [page needed]
  2. ^ a b c Freedberg; et al. (2003). Fitzpatrick's Dermatology in General Medicine (6th ed.). McGraw-Hill. p. 668. ISBN 0-07-138076-0. 
  3. ^ "benign fibrous histiocytoma" at Dorland's Medical Dictionary
  4. ^ "dermatofibroma" at Dorland's Medical Dictionary
  5. ^ a b c Dermatofibroma at eMedicine
  6. ^ Jung, Kyu Dong; Lee, Dong-Youn; Lee, Joo-Heung; Yang, Jun-Mo; Lee, Eil-Soo (2011). "Subcutaneous Dermatofibroma". Annals of Dermatology. 23 (2): 254–7. PMC 3130878Freely accessible. PMID 21747634. doi:10.5021/ad.2011.23.2.254. 
  7. ^ Hanly, A. J.; Jordà, M; Elgart, G. W.; Badiavas, E; Nassiri, M; Nadji, M (2006). "High proliferative activity excludes dermatofibroma: Report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Archives of pathology & laboratory medicine. 130 (6): 831–4. PMID 16740036. doi:10.1043/1543-2165(2006)130[831:HPAEDR]2.0.CO;2 (inactive 2017-01-15). 
  8. ^ Boursicot, Katharine (24 January 2013). Oxford Assess and Progress: Clinical Specialties. Oxford University Press. p. 249. ISBN 9780199657582. 
  9. ^ Kim, H.J.; Lee, J.Y.; Kim, S.H.; Seo, Y.J.; Lee, J.H.; Park, J.K.; Kim, M.H.; Cinn, Y.W.; Cho, K.H.; Yoon, T.Y. (2007). "Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: Comparison with factor XIIIa and CD34". British Journal of Dermatology. 157 (2): 319–24. PMID 17596171. doi:10.1111/j.1365-2133.2007.08033.x. 
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