Close menu

Myxoid liposarcoma

Updated: 2016-09-16T04:33Z
Myxoid liposarcoma
Myxoid liposarcoma (01).jpg
Histopathologic image of myxoid liposarcoma arising in the deep soft tissue of the thigh. H & E stain.
Classification and external resources
SpecialtyLua error in Module:Wikidata at line 288: invalid escape sequence near '"^'.
Patient UKMyxoid liposarcoma
[[[d:Lua error in Module:Wikidata at line 288: invalid escape sequence near '"^'.|edit on Wikidata]]]
Micrograph of myxoid liposarcoma. H&E stain

A myxoid liposarcoma is a malignant adipose tissue neoplasm[1] of myxoid appearance histologically.

Myxoid liposarcomas are the second most common type of liposarcoma, representing 30%–40% of all liposarcomas in the limbs; occurring most commonly in the legs, particularly the thigh, followed by the buttocks, retroperitoneum, trunk, ankle, proximal limb girdle, head and neck, and wrist. They occur in the intermuscular fascial planes or deep-seated areas. They present as a large, slow-growing, painless mass.[2]

They are associated with a fusion between DDIT3 or "CHOP" (at 12q13.1-q13.2) and FUS or "TLS" (at 16p11.2) or EWS (at 22q12.2).[3] [4] [5] The specific translocation of FUS-DDIT3 is t(12;16)(q13;p11).[6] [7]

See also

Further reading


  1. ^ Myxoid/round cell liposarcoma
  2. ^ Sung; et al. (2000). "Myxoid Liposarcoma: Appearance at MR Imaging with Histologic Correlation". RadioGraphics. 20: 1007–1019. doi:10.1148/radiographics.20.4.g00jl021007. 
  3. ^ Rabbitts TH, Forster A, Larson R, Nathan P (1993). "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma". Nat. Genet. 4 (2): 175–80. PMID 7503811. doi:10.1038/ng0693-175. 
  4. ^ Crozat A, Aman P, Mandahl N, Ron D (1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". Nature. 363 (6430): 640–4. PMID 8510758. doi:10.1038/363640a0. 
  5. ^ Forni C, Minuzzo M, Virdis E, et al. (February 2009). "Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors". Mol. Cancer Ther. 8 (2): 449–57. PMID 19190116. doi:10.1158/1535-7163.MCT-08-0848. 
  6. ^ Aman P, Ron D, Mandahl N, et al. (1993). "Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)". Genes Chromosomes Cancer. 5 (4): 278–85. PMID 1283316. doi:10.1002/gcc.2870050403. 
  7. ^ Göransson M, Andersson MK, Forni C, et al. (January 2009). "The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ". Oncogene. 28 (2): 270–8. PMID 18850010. doi:10.1038/onc.2008.378. 

Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.

Also On Wow


    Trending Now