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Primordial germ cell (PGC) migration is the process of distribution of primordial germ cells throughout the embryo during embryogenesis. Process [ edit ] Primordial germ cells are among the first lineages that are established in development [1] and they are the precursors for gametes . [2]
Mitochondrial biogenesis. Mitochondrial biogenesis is the process by which cells increase mitochondrial numbers. [1] [2] It was first described by John Holloszy in the 1960s, when it was discovered that physical endurance training induced higher mitochondrial content levels, leading to greater glucose uptake by muscles. [3]
PGC-1α is a transcriptional regulator for genes involved in fatty acid oxidation, gluconeogenesis, and is considered the master regulator for mitochondrial biogenesis. To do this, it enhances the activity of transcription factors like nuclear respiratory factor 1 , myocyte enhancer factor 2 (MEF2), host cell factor (HCF), and others.
PPARGC1A. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ( PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. [4] PPARGC1A is also known as human accelerated region 20 ( HAR20 ). It may, therefore, have played a key role in differentiating humans from apes. [5]
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Step by Step. (TV series) Step by Step is an American television sitcom created by William Bickley and Michael Warren that ran on ABC as part of its TGIF Friday night lineup from September 20, 1991, to August 15, 1997, then moved to CBS, where it aired from September 19, 1997, to June 26, 1998, with a total of 160 half-hour episodes spanning ...
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The Pennsylvania Game Commission (PGC) is the state agency responsible for wildlife conservation and management in Pennsylvania in the United States.It was originally founded 129 years ago and currently utilizes more than 700 full-time employees and thousands of part-time and volunteers in its official mission to "manage and protect wildlife and their habitats while promoting hunting and ...