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For correlated random variables the sample variance needs to be computed according to the Markov chain central limit theorem.. Independent and identically distributed random variables with random sample size
The topic of heteroskedasticity-consistent ( HC) standard errors arises in statistics and econometrics in the context of linear regression and time series analysis. These are also known as heteroskedasticity-robust standard errors (or simply robust standard errors ), Eicker–Huber–White standard errors (also Huber–White standard errors or ...
Definition and basic properties. The MSE either assesses the quality of a predictor (i.e., a function mapping arbitrary inputs to a sample of values of some random variable), or of an estimator (i.e., a mathematical function mapping a sample of data to an estimate of a parameter of the population from which the data is sampled).
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Huber-White standard errors assume is diagonal but that the diagonal value varies, while other types of standard errors (e.g. Newey–West, Moulton SEs, Conley spatial SEs) make other restrictions on the form of this matrix to reduce the number of parameters that the practitioner needs to estimate.
where represents the standard deviation of the function , represents the standard deviation of , represents the standard deviation of , and so forth.. It is important to note that this formula is based on the linear characteristics of the gradient of and therefore it is a good estimation for the standard deviation of as long as ,,, … are small enough.
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In bioinformatics, the root mean square deviation of atomic positions is the measure of the average distance between the atoms of superimposed proteins. In structure based drug design, the RMSD is a measure of the difference between a crystal conformation of the ligand conformation and a docking prediction.