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Interstate 77. Interstate 77 (I-77) is a north–south Interstate Highway in the Eastern United States. It traverses diverse terrain, from the mountainous state of West Virginia to the rolling farmlands of North Carolina and Ohio. It largely supplants the old U.S. Route 21 (US 21) between Cleveland, Ohio, and Columbia, South Carolina, as an ...
U.S. Route 50 (US 50) runs east–west across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts. Near Athens it runs concurrently with State Route 32 (SR 32), a four-lane divided highway known as Corridor D, and from ...
U.S. Route 25 (US 25) is a 140.600-mile (226.274 km) United States Numbered Highway that travels from Brunswick, Georgia, to the Kentucky – Ohio state line, where Covington, Kentucky, meets Cincinnati, Ohio, at the Ohio River. In the U.S. state of South Carolina, it travels south to north in the western part of the state, serving the northern ...
US 321 provides direct access between Savannah and Columbia, serving as an alternate to Interstate 95 and Interstate 26.Starting in Hardeeville, US 321 as a mostly 2 lane highway goes through sparsely populated areas and small towns including Estill, Fairfax, and Denmark, heading in a rather straight and northward direction into the Columbia area, widening to a 5 lane highway right after ...
SC. → SC 381. U.S. Route 378 (US 378) is a spur of US 78 in the U.S. states of Georgia and South Carolina. The U.S. Highway runs 234.30 miles (377.07 km) from US 78, Georgia State Route 10 (SR 10), SR 17, and SR 47 in Washington, Georgia, east to US 501 Business in Conway, South Carolina. US 378 connects the Central Savannah River Area in ...
U.S. Highway 1 (US 1) is a 170.540-mile (274.458 km) north–south U.S. Highway that crosses South Carolina from southwest to northeast and connects the cities of North Augusta, Aiken, Lexington, Columbia, Camden, and Cheraw. The route parallels Interstate 20 (I-20) closely from the Georgia border to Camden, where I-20 turns to a more directly ...
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