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U.S. Route 25 (US 25) is a 140.600-mile (226.274 km) United States Numbered Highway that travels from Brunswick, Georgia, to the Kentucky – Ohio state line, where Covington, Kentucky, meets Cincinnati, Ohio, at the Ohio River. In the U.S. state of South Carolina, it travels south to north in the western part of the state, serving the northern ...
U.S. Route 50 (US 50) runs east–west across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts. Near Athens it runs concurrently with State Route 32 (SR 32), a four-lane divided highway known as Corridor D, and from ...
Interstate 77. Interstate 77 (I-77) is a north–south Interstate Highway in the Eastern United States. It traverses diverse terrain, from the mountainous state of West Virginia to the rolling farmlands of North Carolina and Ohio. It largely supplants the old U.S. Route 21 (US 21) between Cleveland, Ohio, and Columbia, South Carolina, as an ...
WV. → WV 23. U.S. Route 22 (US 22) is a major east–west route and one of the original United States Numbered Highways, founded in 1926. It runs from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at US 1/9 at the Newark Airport Interchange. [3]
3.6 mi (5.8 km) U.S. Route 321 Truck (US 321 Truck) redirects truckers traveling south on US 321 around downtown. It shares a concurrency with US 11E and SR 70. The route begins at US 11E/US 321 and ends 3.6 miles (5.8 km) later at US 321/SR 70. The entire route is in Greeneville, Greene County. mi. km.
U.S. Route 52 (US 52) runs east–west across the southern part of the state of Ohio along the Ohio River, passing through or very near the cities and towns of Cincinnati, Portsmouth, and Ironton. For its first 19 miles (31 km) or so, the highway runs concurrently with Interstate 74 (I-74) and I-75 before it winds through downtown Cincinnati ...
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