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Half-life (symbol t½) is the time required for a quantity (of substance) to reduce to half of its initial value. The term is commonly used in nuclear physics to describe how quickly unstable atoms undergo radioactive decay or how long stable atoms survive. The term is also used more generally to characterize any type of exponential (or, rarely ...
Specific activity. In the context of radioactivity, activity or total activity (symbol A) is a physical quantity defined as the number of radioactive transformations per second that occur in a particular radionuclide. [1] The unit of activity is the becquerel (symbol Bq), which is defined equivalent to reciprocal seconds (symbol s -1 ).
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
A more intuitive characteristic of exponential decay for many people is the time required for the decaying quantity to fall to one half of its initial value. (If N(t) is discrete, then this is the median life-time rather than the mean life-time.) This time is called the half-life, and often denoted by the symbol t 1/2. The half-life can be ...
Effective half-life. In pharmacokinetics, the effective half-life is the rate of accumulation or elimination of a biochemical or pharmacological substance in an organism; it is the analogue of biological half-life when the kinetics are governed by multiple independent mechanisms. This is seen when there are multiple mechanisms of elimination ...
As an extreme example, the half-life of the isotope bismuth-209 is 2.01 × 10 19 years. The isotopes in beta-decay stable isobars that are also stable with regards to double beta decay with mass number A = 5, A = 8, 143 ≤ A ≤ 155, 160 ≤ A ≤ 162, and A ≥ 165 are theorized to undergo alpha decay.
Cobalt-60 ( 60 Co) is a synthetic radioactive isotope of cobalt with a half-life of 5.2714 years. [3] [4] : 39 It is produced artificially in nuclear reactors. Deliberate industrial production depends on neutron activation of bulk samples of the monoisotopic and mononuclidic cobalt isotope 59. Co. . [5]
Clearance (pharmacology) In pharmacology, clearance ( ) is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [1] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.