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Online access. Online archive. Toxicological Sciences is a monthly peer-reviewed scientific journal which covers all aspects of research on toxicology. It is published by Oxford University Press on behalf of the Society of Toxicology. It was established in 1981 as Fundamental and Applied Toxicology and obtained its current name in 1998.
Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms [ 1 ] and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed ...
The threshold of toxilogical concern (or TTC) is a method for determining the level of exposure to chemicals above which would be considered toxic, [1] in cases where data about such chemicals is scarce or non-existent. [2][3][4][5][6]
It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity. It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans. However, it can also be used in environmental risk assessments ...
The discipline of evidence-based toxicology ( EBT) strives to transparently, consistently, and objectively assess available scientific evidence in order to answer questions in toxicology, [1] the study of the adverse effects of chemical, physical, or biological agents on living organisms and the environment, including the prevention and ...
Environmental toxicology is a multidisciplinary field of science concerned with the study of the harmful effects of various chemical, biological and physical agents on living organisms. [1][2] Ecotoxicology is a subdiscipline of environmental toxicology concerned with studying the harmful effects of toxicants at the population and ecosystem ...
U.S. Army Public Health Center Toxicology Lab technician assessing samples. Toxicology testing, also known as safety assessment, or toxicity testing, is the process of determining the degree to which a substance of interest negatively impacts the normal biological functions of an organism, given a certain exposure duration, route of exposure, and substance concentration.
In pharmaceutical research, toxicogenomics is defined as the study of the structure and function of the genome as it responds to adverse xenobiotic exposure. It is the toxicological subdiscipline of pharmacogenomics, which is broadly defined as the study of inter-individual variations in whole-genome or candidate gene single-nucleotide polymorphism maps, haplotype markers, and alterations in ...