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Cyclic ADP-ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine (like ADP), further connected to another ribose at the 5' position, which, in turn, closes the cycle by glycosidic bonding to the nitrogen 1 (N 1) of the same adenine base (whose position N 9 has the glycosidic bond to the other ribose).
ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. [1] [2] It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. [3] [4] Improper ADP-ribosylation has been implicated in some forms of cancer. [5]
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ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene. [3] Identical copies of this gene reside on the pseudoautosomal regions of the X and Y chromosomes .
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Principal language families of the world (and in some cases geographic groups of families). For greater detail, see Distribution of languages in the world.. This is a list of languages by total number of speakers.
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For international access the NANP is assigned the country code 1, which is dialed as a prefix in the international E.164 telephone numbering plan.. The trunk prefix for dialing long-distance calls, across numbering plan area (NPA) boundaries within Canada or to other NANP countries, is also 1.