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Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a ...
Somatic evolution in cancer. Somatic evolution is the accumulation of mutations and epimutations in somatic cells (the cells of a body, as opposed to germ plasm and stem cells) during a lifetime, and the effects of those mutations and epimutations on the fitness of those cells. This evolutionary process has first been shown by the studies of ...
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. [2] [7] These contrast with benign tumors, which do not spread. [7] Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. [1]
Cancer prevention. Cancer prevention is the practice of taking active measures to decrease the incidence of cancer and mortality. [1] [2] The practice of prevention is dependent upon both individual efforts to improve lifestyle and seek preventive screening, and socioeconomic or public policy related to cancer prevention. [3]
Maytenus ovatus. Trastuzumab emtansine (Kadcyla) is an antibody conjugated to a synthetic derivative of the cytotoxic principle of the Ethiopian plant Maytenus ovatus. It used to treat breast cancer. [10] Mappia foetida. Some of the research has been showed that it has an effective anticancer property against breast cancer [1]
Malignant transformation. Malignant transformation is the process by which cells acquire the properties of cancer. This may occur as a primary process in normal tissue, or secondarily as malignant degeneration of a previously existing benign tumor .
Cancer is caused by genetic changes leading to uncontrolled cell growth and tumor formation. The basic cause of sporadic (non-familial) cancers is DNA damage and genomic instability. [1] [2] A minority of cancers are due to inherited genetic mutations. [3] Most cancers are related to environmental, lifestyle, or behavioral exposures. [4]
It also collects and publishes surveillance data regarding the occurrence of cancer worldwide. Its Monographs Programme identifies carcinogenic hazards and evaluates environmental causes of cancer in humans. Structure and governance. The World Health Organization is a member of the United Nations Development Group. Membership
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