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ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. [1] [2] It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. [3] [4] Improper ADP-ribosylation has been implicated in some forms of cancer. [5]
Cyclic ADP-ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine (like ADP), further connected to another ribose at the 5' position, which, in turn, closes the cycle by glycosidic bonding to the nitrogen 1 (N 1) of the same adenine base (whose position N 9 has the glycosidic bond to the other ribose).
Platelet-rich human blood plasma (left vial) is a turbid liquid. Upon addition of ADP, platelets are activated and start to aggregate, forming white flakes (right vial) Hemostasis occurs when blood is present outside of the body or blood vessels. It is the innate response for the body to stop bleeding and loss of blood.
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In human anatomy, the penis (/ ˈ p iː n ɪ s /; pl.: penises or penes; from the Latin pēnis, initially "tail" [1]) is an external male sex organ (intromittent organ) that serves as a passage for excretion of urine and ejaculation of semen.
Mia Khalifa (/ m iː ə k ə ˈ l iː f ə /; Arabic: ميا خليفة Miyа̄ Ḵalīfah [mijaː χaliːfa(h)]; born 1993 [1]) is a Lebanese-American media personality and former pornographic film actress and webcam model.