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The Philadelphia chromosome or Philadelphia translocation ( Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells). This chromosome is defective and unusually short because of reciprocal translocation, t (9;22) (q34;q11), of genetic material between chromosome 9 and ...
Ophthalmology. In ophthalmology, horror fusionis is a condition in which the eyes have an unsteady deviation, with the extraocular muscles performing spasm-like movements that continuously shift the eyes away from the position in which they would be directed to the same point in space, giving rise to diplopia. Even when the double vision images ...
ALK positive lung cancer is a primary malignant lung tumor whose cells contain a characteristic abnormal configuration of DNA wherein, most frequently, the echinoderm microtubule-associated protein-like 4 ( EML4) gene is fused to the anaplastic lymphoma kinase ( ALK) gene. Less frequently, there will be novel translocation partners for the ALK ...
assess degree of binocular vision. The Worth Four Light Test, also known as the Worth's four dot test or W4LT, is a clinical test mainly used for assessing a patient's degree of binocular vision and binocular single vision. Binocular vision involves an image being projected by each eye simultaneously into an area in space and being fused into a ...
Carpal coalition is the abnormal fusion of two or more carpal bones when they fail to segment during intrauterine development. [1] First described by Eduard Sandifort in 1779, carpal coalitions are often an isolated issue which connect two carpal bones in the same row of the wrist. [2] These issues are congenital and occur at various rates ...
Identification. Anaplastic lymphoma kinase (ALK) was originally discovered in 1994 [5] [7] in anaplastic large-cell lymphoma (ALCL) cells. ALCL is caused by a (2;5) (p23:q35) chromosomal translocation that generates the fusion protein NPM-ALK, in which the kinase domain of ALK is fused to the amino-terminal part of the nucleophosmin (NPM) protein.
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