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Crystal structure of Akt-2-inhibitor complexes. [2] Protein kinase B ( PKB ), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration .
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Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species. PBPK modeling is used in pharmaceutical research and drug development, and in health risk ...
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A personal knowledge base ( PKB) is an electronic tool used to express, capture, and later retrieve the personal knowledge of an individual. It differs from a traditional database in that it contains subjective material particular to the owner, that others may not agree with nor care about. Importantly, a PKB consists primarily of knowledge ...
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PDPK1 is a master kinase, which is crucial for the activation of AKT /PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signaling pathways activated by several growth factors and hormones including insulin signaling. Mice lacking PDPK1 die during early embryonic development, indicating that this ...