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Hereditary haemochromatosis type 1 ( HFE-related Hemochromatosis) [3] is a genetic disorder characterized by excessive intestinal absorption of dietary iron, resulting in a pathological increase in total body iron stores. [4] Humans, like most animals, have no mechanism to regulate excess iron, simply losing a limited amount through various ...
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HFE H63D gene mutation. The HFE H63D is a single-nucleotide polymorphism in the HFE gene (c.187C>G, rs1799945), which results in the substitution of a histidine for an aspartic acid at amino acid position 63 of the HFE protein (p.His63Asp). HFE participates in the regulation of iron absorption.
Hfe is the mouse equivalent of the human hemochromatosis gene HFE. The protein encoded by HFE is Hfe. Mice homozygous (two abnormal gene copies) for a targeted knockout of all six transcribed Hfe exons are designated Hfe −/−. [29] Iron-related traits of Hfe −/− mice, including increased iron absorption and hepatic iron loading, are ...
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They are sometimes applied as blends such as HFE 7100, which is a mixture of methyl nonafluorobutyl ether (methoxyperfluorobutane) and methyl nonafluoroisobutyl ether. [2] 3M produces hydrofluoroether compounds under the names Novec 7000, 7100, 7200, 7300, 7500, and 7700 as liquid coolants for many applications including full immersion cooling ...
On 6 and 9 August 1945, the United States detonated two atomic bombs over the Japanese cities of Hiroshima and Nagasaki. The bombings killed between 129,000 and 226,000 people, most of whom were civilians, and remain the only use of nuclear weapons in an armed conflict. Japan surrendered to the Allies on 15 August, six days after the bombing of ...