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ATP hydrolysis. ATP hydrolysis is the catabolic reaction process by which chemical energy that has been stored in the high-energy phosphoanhydride bonds in adenosine triphosphate (ATP) is released after splitting these bonds, for example in muscles, by producing work in the form of mechanical energy. The product is adenosine diphosphate (ADP ...
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PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. [1] Several forms of cancer are more dependent on PARP than regular cells, making PARP ( PARP1, PARP2 etc.) an attractive target for cancer therapy.
View/Edit Human. View/Edit Mouse. P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) [5] [6] that belongs to the G i class of a group of G protein-coupled (GPCR) purinergic receptors. [7] This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine ...
Cangrelor. ~97–98%. Cangrelor, sold under the brand name Kengreal among others, is a P2Y 12 inhibitor FDA approved as of June 2015 as an antiplatelet drug [5] for intravenous application. Some P2Y 12 inhibitors are used clinically as effective inhibitors of adenosine diphosphate -mediated platelet activation and aggregation. [5]
The enzyme ADP-phosphoglycerate phosphatase (EC 3.1.3.28) catalyzes the reaction. This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is 3- (ADP)-2-phosphoglycerate phosphohydrolase. This enzyme is also called adenosine diphosphate phosphoglycerate phosphatase .
GrpE. GrpE ( Gro-P like protein E) is a bacterial nucleotide exchange factor that is important for regulation of protein folding machinery, as well as the heat shock response. [1] It is a heat-inducible protein and during stress it prevents unfolded proteins from accumulating in the cytoplasm. [2] [3] Accumulation of unfolded proteins in the ...
e. Countervailing duties ( CVDs ), also known as anti-subsidy duties, are trade import duties imposed under World Trade Organization (WTO) rules to neutralize the negative effects of subsidies. They are imposed after an investigation finds that a foreign country subsidizes its exports, injuring domestic producers in the importing country.
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