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  2. Losartan - Wikipedia

    en.wikipedia.org/wiki/Losartan

    Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). [4] It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys.

  3. Losartan/hydrochlorothiazide - Wikipedia

    en.wikipedia.org/wiki/Losartan/hydrochlorothiazide

    Losartan/hydrochlorothiazide, sold under the brand name Hyzaar among others, is a fixed-dose combination medication used to treat high blood pressure when losartan is not sufficient. [1][2] It consists of losartan (an angiotensin II receptor blocker) and hydrochlorothiazide (a thiazide diuretic). [1][2] It is taken by mouth. [1][2] Common side ...

  4. Angiotensin II receptor blocker - Wikipedia

    en.wikipedia.org/wiki/Angiotensin_II_receptor...

    Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...

  5. Discovery and development of angiotensin receptor blockers

    en.wikipedia.org/wiki/Discovery_and_development...

    Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5-carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [17] and has been a model for the continuing development of several other ARBs. [1]

  6. Antihypertensive - Wikipedia

    en.wikipedia.org/wiki/Antihypertensive

    Antihypertensive. Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). [1] Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can ...

  7. ACE inhibitor - Wikipedia

    en.wikipedia.org/wiki/ACE_inhibitor

    Common side effects include: low blood pressure, cough, hyperkalemia, headache, dizziness, fatigue, nausea, and kidney impairment. [18][19] The main adverse effects of ACE inhibition can be understood from their pharmacological action. The other reported adverse effects are liver problems and effects on the fetus. [19]

  8. ACE inhibitor and thiazide combination - Wikipedia

    en.wikipedia.org/wiki/ACE_inhibitor_and_thiazide...

    An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension (high blood pressure). They are given by mouth. ACE inhibitors reduce the activity of angiotensin-converting enzyme (ACE) which produces angiotensin II, a hormone that constricts blood vessels. Thiazides are a class of diuretics that inhibit the thiazide ...

  9. Uricosuric - Wikipedia

    en.wikipedia.org/wiki/Uricosuric

    Drugs with other primary uses, that have known uricosuric properties, include losartan, [1] atorvastatin, and fenofibrate.Although these drugs may have significant uricosuric action, their other significant pharmacological actions in off-label use as a uricosuric requires careful assessment of the patient to achieve the most benefit and least risk.

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