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  2. Oxidative stress - Wikipedia

    en.wikipedia.org/wiki/Oxidative_stress

    Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

  3. Neuroprotection - Wikipedia

    en.wikipedia.org/wiki/Neuroprotection

    Antioxidants are the primary treatment used to control oxidative stress levels. Antioxidants work to eliminate reactive oxygen species, which are the prime cause of neurodegradation. The effectiveness of antioxidants in preventing further neurodegradation is not only disease dependent but can also depend on gender, ethnicity, and age.

  4. Reactive oxygen species - Wikipedia

    en.wikipedia.org/wiki/Reactive_oxygen_species

    This may result in significant damage to cell structures. Cumulatively, this is known as oxidative stress. The production of ROS is strongly influenced by stress factor responses in plants, these factors that increase ROS production include drought, salinity, chilling, defense of pathogens, nutrient deficiency, metal toxicity and UV-B radiation.

  5. Glutathione reductase - Wikipedia

    en.wikipedia.org/wiki/Glutathione_reductase

    Glutathione reductase (GR) also known as glutathione-disulfide reductase (GSR) is an enzyme that in humans is encoded by the GSR gene.Glutathione reductase (EC 1.8.1.7) catalyzes the reduction of glutathione disulfide to the sulfhydryl form glutathione (), which is a critical molecule in resisting oxidative stress and maintaining the reducing environment of the cell.

  6. Reperfusion injury - Wikipedia

    en.wikipedia.org/wiki/Reperfusion_injury

    Reperfusion injury, sometimes called ischemia-reperfusion injury ( IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue ( re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia ). The absence of oxygen and nutrients from blood during the ischemic period creates a condition in ...

  7. Hyperhomocysteinemia - Wikipedia

    en.wikipedia.org/wiki/Hyperhomocysteinemia

    Hyperhomocysteinemia is a medical condition characterized by an abnormally high level of total homocysteine (that is, including homocystine and homocysteine-cysteine disulfide) in the blood, conventionally described as above 15 μmol/L. [1] As a consequence of the biochemical reactions in which homocysteine is involved, deficiencies of vitamin ...

  8. Antioxidant - Wikipedia

    en.wikipedia.org/wiki/Antioxidant

    As with the chemical antioxidants, cells are protected against oxidative stress by an interacting network of antioxidant enzymes. Here, the superoxide released by processes such as oxidative phosphorylation is first converted to hydrogen peroxide and then further reduced to give water. This detoxification pathway is the result of multiple ...

  9. Xanthine oxidase - Wikipedia

    en.wikipedia.org/wiki/Xanthine_oxidase

    Xanthine oxidase ( XO, sometimes 'XAO ') is a form of xanthine oxidoreductase, a type of enzyme that generates reactive oxygen species. [2] These enzymes catalyze the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. These enzymes play an important role in the catabolism of purines in some ...

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