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Adenosine diphosphate ribose (ADPR) is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. [1] ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD +) as a cofactor. [1] ADPR binds to and activates the TRPM2 ion channel. [2] ADPR is the most potent agonist of ...
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Employee motivation is an intrinsic and internal drive to put forth the necessary effort and action towards work-related activities. It has been broadly defined as the "psychological forces that determine the direction of a person's behavior in an organisation, a person's level of effort and a person's level of persistence". [1]
Ross Perot was born in Texarkana, Texas in 1930, the son of Lula May (née Ray) and Gabriel Ross Perot, [3] a commodity broker specializing in cotton contracts. [4] [5] He had an older brother, Gabriel Perot Jr., who died as a toddler. [6]
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The Macro domain recognises the ADP-ribose nucleotide and in some cases poly-ADP-ribose, and is thus a high-affinity ADP-ribose-binding module found in a number of otherwise unrelated proteins. ADP-ribosylation of DNA is relatively uncommon and has only been described for a small number of toxins that include pierisin, [12] scabin [13] and DarT.
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