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  2. Depression (mood) - Wikipedia

    en.wikipedia.org/wiki/Depression_(mood)

    e. Depression is a mental state of low mood and aversion to activity. [3] It affects about 3.5% of the global population, or about 280 million people of all ages (as of 2020). [4] Depression affects a person's thoughts, behavior, feelings, and sense of well-being. [5]

  3. Major depressive disorder - Wikipedia

    en.wikipedia.org/wiki/Major_depressive_disorder

    Major depressive disorder (MDD), also known as clinical depression, is a mental disorder [ 9 ] characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, [ 10 ] the term was adopted by the American ...

  4. Long-term depression - Wikipedia

    en.wikipedia.org/wiki/Long-term_depression

    Long-term depression. In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress. [1]

  5. Major depressive episode - Wikipedia

    en.wikipedia.org/wiki/Major_depressive_episode

    A major depressive episode (MDE) is a period characterized by symptoms of major depressive disorder. Those affected primarily exhibit a depressive mood for at least two weeks or more, and a loss of interest or pleasure in everyday activities. Other symptoms can include feelings of emptiness, hopelessness, anxiety, worthlessness, guilt ...

  6. Mood disorder - Wikipedia

    en.wikipedia.org/wiki/Mood_disorder

    Depressive disorder (also known as depression) is a common mental disorder. It involves a depressed mood or loss of pleasure or interest in activities for long periods of time. Depression is different from regular mood changes and feelings about everyday life. It can affect all aspects of life.

  7. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    Biology of depression. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD), [ 1 ] and this has encouraged advocates of various theories that seek to identify a biochemical origin of the disease, as opposed to theories that emphasize psychological or situational causes.

  8. History of depression - Wikipedia

    en.wikipedia.org/wiki/History_of_depression

    In the mid-20th century, researchers theorized that depression was caused by a chemical imbalance in neurotransmitters in the brain, a theory based on observations made in the 1950s of the effects of reserpine and isoniazid in altering monoamine neurotransmitter levels and affecting depressive symptoms. [32]

  9. Depression in childhood and adolescence - Wikipedia

    en.wikipedia.org/wiki/Depression_in_childhood...

    The more pertinent controversy in psychology today centers around the clinical significance of sub-threshold mood disorders. This controversy stems from the debate regarding the definition of the specific criteria for a clinically significant depressed mood in relation to the cognitive and behavioral symptoms.

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