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Adenosine diphosphate ribose (ADPR) is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD +) as a cofactor. ADPR binds to and activates the TRPM2 ion channel. ADPR is the most potent agonist of the TRPM2 ...
Once PARP detects a SSB, it binds to the DNA, undergoes a structural change, and begins the synthesis of a polymeric adenosine diphosphate ribose (poly (ADP-ribose) or PAR) chain, which acts as a signal for the other DNA-repairing enzymes. Target enzymes include DNA ligase III (LigIII), DNA polymerase beta (polβ), and scaffolding proteins such ...
Payroll taxes are taxes imposed on employers or employees, and are usually calculated as a percentage of the salaries that employers pay their employees. [1] By law, some payroll taxes are the responsibility of the employee and others fall on the employer, but almost all economists agree that the true economic incidence of a payroll tax is ...
Cyclic ADP-ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine (like ADP), further connected to another ribose at the 5' position, which, in turn, closes the cycle by glycosidic bonding to the nitrogen 1 (N 1) of the same adenine base (whose position N 9 has the glycosidic bond to the other ribose).
The enzyme ADP-phosphoglycerate phosphatase (EC 3.1.3.28) catalyzes the reaction. This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is 3- (ADP)-2-phosphoglycerate phosphohydrolase. This enzyme is also called adenosine diphosphate phosphoglycerate phosphatase .
Groupe ADP, formerly Aéroports de Paris or ADP (Paris Airports), is an international airport operator based in Paris (France). Groupe ADP owns and manages Parisian international airports Charles de Gaulle Airport , Orly Airport and Le Bourget Airport , all gathered under the brand Paris Aéroport since 2016.
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