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Empagliflozin, sold under the brand name Jardiance, among others, is an antidiabetic medication used to improve glucose control in people with type 2 diabetes. [10] [2] [12] It is taken by mouth . [2]
Empagliflozin and linagliptin addresses different aspects of glucose regulation. Empagliflozin primarily focuses on reducing glucose reabsorption in the kidneys, while linagliptin enhances the body's natural insulin response and reduces glucagon secretion. Together, these mechanisms help lower blood glucose levels in individuals with type 2 ...
The most common side effects include hypoglycaemia (low blood sugar levels) when the medicine is taken with a sulphonylurea or insulin, infections of the urinary tract and genitals, and increased urination.
The cardioprotective effects of SGLT2 inhibitors have been attributed to the elevated ketone levels. [59] Gliflozins have been posited to exhibit protective effects on the heart, liver, kidneys, anti‐hyperlipidemic, anti‐ atherosclerotic , anti‐ obesity , anti‐ neoplastic effects in in vitro , pre‐clinical, and clinical studies.
Adverse effects. To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before scheduled surgery.
Thiazolidinedione. Functional group. The thiazolidinediones / θaɪ.əˌzoʊlɪdiːnˈdaɪ.oʊn /, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, [1] are a class of heterocyclic compounds consisting of a five-membered C 3 NS ring. The term usually refers to a family of drugs used in the treatment of ...