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The integrated stress response is a cellular stress response conserved in eukaryotic cells that downregulates protein synthesis and upregulates specific genes in response to internal or environmental stresses. [1] Contents 1 Background 2 eIF2 protein complex 3 Protein kinases 3.1 PERK 3.2 HRI 3.3 GCN2 3.4 PKR 4 ATF4
Stress has a role in humans as a method of reacting to difficult and possibly dangerous situations. The "fight or flight" response when one perceives a threat helps the body exert energy to fight or run away to live another day.
Stress is the body's method of reacting to a condition such as a threat, challenge or physical and psychological barrier. There are two hormones that an individual produces during a stressful situation, these are well known as adrenaline and cortisol. [2] There are two kinds of stress hormone levels.
The fight-or-flight or the fight-flight-or-freeze response (also called hyperarousal or the acute stress response) is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival. [1] It was first described by Walter Bradford Cannon. [a] [2] His theory states that animals react to threats with a ...
Hans Selye. János Hugo Bruno " Hans " Selye CC ( / ˈsɛljeɪ / [dubious – discuss]; Hungarian: Selye János Hungarian pronunciation: [ˈʃɛjɛ]; January 26, 1907 – October 16, 1982) was a pioneering Hungarian-Canadian endocrinologist who conducted important scientific work on the hypothetical non-specific response of an organism to ...
Protection motivation theory (PMT) was originally created to help understand individual human responses to fear appeals. Protection motivation theory proposes that people protect themselves based on two factors: threat appraisal and coping appraisal. Threat appraisal assesses the severity of the situation and examines how serious the situation ...
The stimulus–response model is a characterization of a statistical unit (such as a neuron ). The model allows the prediction of a quantitative response to a quantitative stimulus, for example one administered by a researcher. In psychology, stimulus response theory concerns forms of classical conditioning in which a stimulus becomes paired ...