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Adenosine 5′- (γ-thiotriphosphate) is an extremely common ATP analog in which one of the gamma-phosphate oxygens is replaced by a sulfur atom; this anion is hydrolyzed at a dramatically slower rate than ATP itself and functions as an inhibitor of ATP-dependent processes.
ADP binds behind the NAD-BD, just beneath the pivot helix - in the special ADP allosteric site. The adenosine moiety binds down into a hydrophobic pocket, with the ribose phosphate groups pointing outside towards the GTP allosteric site. NADH can also bind to the ADP site, when at high concentrations, usually resulting in the enzyme inhibition.
Guanosine-5'-triphosphate ( GTP) is a purine nucleoside triphosphate. It is one of the building blocks needed for the synthesis of RNA during the transcription process. Its structure is similar to that of the guanosine nucleoside, the only difference being that nucleotides like GTP have phosphates on their ribose sugar.
On October 1, 2014, ADP Dealer Services division was spun-off to form the independent company CDK Global. The CDK in the company's name was inspired from different acquisitions; C from Cobalt Digital Marketing, [18] D from the original ADP Dealer Services business, and K from Kerridge Computer Company, a UK-based DMS supplier acquired by ADP in ...
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. [1] Several forms of cancer are more dependent on PARP than regular cells, making PARP ( PARP1, PARP2 etc.) an attractive target for cancer therapy.
Substrate-level phosphorylation exemplified with the conversion of ADP to ATP. Substrate-level phosphorylation is a metabolism reaction that results in the production of ATP or GTP supported by the energy released from another high-energy bond that leads to phosphorylation of ADP or GDP to ATP or GTP (note that the reaction catalyzed by creatine kinase is not considered as "substrate-level ...
The English word Germany derives from the Latin Germania, which came into use after Julius Caesar adopted it for the peoples east of the Rhine. The German term Deutschland, originally diutisciu land ('the German lands') is derived from deutsch (cf. Dutch), descended from Old High German diutisc 'of the people' (from diot or diota 'people'), originally used to distinguish the language of the ...
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